The clinical and virological features of the first imported case causing MERS-CoV outbreak in South Korea, 2015
Identifieur interne : 000B56 ( Main/Exploration ); précédent : 000B55; suivant : 000B57The clinical and virological features of the first imported case causing MERS-CoV outbreak in South Korea, 2015
Auteurs : Ji Yeon Lee [Corée du Sud] ; You-Jin Kim [Corée du Sud] ; Eun Hee Chung [Corée du Sud] ; Dae-Won Kim [Corée du Sud] ; Ina Jeong [Corée du Sud] ; Yeonjae Kim [Corée du Sud] ; Mi-Ran Yun [Corée du Sud] ; Sung Soon Kim [Corée du Sud] ; Gayeon Kim [Corée du Sud] ; Joon-Sung Joh [Corée du Sud]Source :
- BMC Infectious Diseases [ 1471-2334 ] ; 2017.
Descripteurs français
- KwdFr :
- Antiviraux (usage thérapeutique), Arabie saoudite (épidémiologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Flambées de maladies, Humains, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (épidémiologie), Infections à coronavirus (étiologie), Lutte contre l'infection (), Moyen Orient, Mâle, Phylogénie, Ribavirine (usage thérapeutique), République de Corée (épidémiologie), Sujet âgé.
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus.
- usage thérapeutique : Antiviraux, Ribavirine.
- épidémiologie : Arabie saoudite, Infections à coronavirus, République de Corée.
- étiologie : Infections à coronavirus.
- Flambées de maladies, Humains, Lutte contre l'infection, Moyen Orient, Mâle, Phylogénie, Sujet âgé.
English descriptors
- KwdEn :
- Aged, Antiviral Agents (therapeutic use), Coronavirus Infections (drug therapy), Coronavirus Infections (epidemiology), Coronavirus Infections (etiology), Disease Outbreaks, Humans, Infection Control (methods), Male, Middle East, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Middle East Respiratory Syndrome Coronavirus (pathogenicity), Phylogeny, Republic of Korea (epidemiology), Ribavirin (therapeutic use), Saudi Arabia (epidemiology).
- MESH :
- chemical , therapeutic use : Antiviral Agents, Ribavirin.
- drug therapy : Coronavirus Infections.
- epidemiology : Coronavirus Infections, Republic of Korea, Saudi Arabia.
- etiology : Coronavirus Infections.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- methods : Infection Control.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus.
- Aged, Disease Outbreaks, Humans, Male, Middle East, Phylogeny.
Abstract
In 2015, the largest outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection outside the Middle East occurred in South Korea. We summarized the epidemiological, clinical, and laboratory findings of the first Korean case of MERS-CoV and analyzed whole-genome sequences of MERS-CoV derived from the patient.
A 68-year-old man developed fever and myalgia 7 days after returning to Korea, following a 10-day trip to the Middle East. Before diagnosis, he visited 4 hospitals, potentially resulting in secondary transmission to 28 patients. On admission to the National Medical Center (day 9, post-onset of clinical illness), he presented with drowsiness, hypoxia, and multiple patchy infiltrations on the chest radiograph. He was intubated (day 12) because of progressive acute respiratory distress syndrome (ARDS) and INF-α2a and ribavirin treatment was commenced. The treatment course was prolonged by superimposed ventilator associated pneumonia. MERS-CoV PCR results converted to negative from day 47 and the patient was discharged (day 137), following rehabilitation therapy. The complete genome sequence obtained from a sputum sample (taken on day 11) showed the highest sequence similarity (99.59%) with the virus from an outbreak in Riyadh, Saudi Arabia, in February 2015.
The first case of MERS-CoV infection had high transmissibility and was associated with a severe clinical course. The patient made a successful recovery after early treatment with antiviral agents and adequate supportive care. This first case in South Korea became a super-spreader because of improper infection control measures, rather than variations of the virus.
Url:
DOI: 10.1186/s12879-017-2576-5
PubMed: 28709419
PubMed Central: 5512736
Affiliations:
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last="Joh">Joon-Sung Joh</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1773 6903</institution-id><institution-id institution-id-type="GRID">grid.415619.e</institution-id><institution>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center,</institution></institution-wrap>Seoul, 04564 Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiviral Agents (therapeutic use)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (etiology)</term><term>Disease Outbreaks</term><term>Humans</term><term>Infection Control (methods)</term><term>Male</term><term>Middle East</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term><term>Phylogeny</term><term>Republic of Korea (epidemiology)</term><term>Ribavirin (therapeutic use)</term><term>Saudi Arabia (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (usage thérapeutique)</term><term>Arabie saoudite (épidémiologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term><term>Flambées de maladies</term><term>Humains</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (épidémiologie)</term><term>Infections à coronavirus (étiologie)</term><term>Lutte contre l'infection ()</term><term>Moyen Orient</term><term>Mâle</term><term>Phylogénie</term><term>Ribavirine (usage thérapeutique)</term><term>République de Corée (épidémiologie)</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Ribavirin</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Republic of Korea</term><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Infection Control</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Ribavirine</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Arabie saoudite</term><term>Infections à coronavirus</term><term>République de Corée</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Disease Outbreaks</term><term>Humans</term><term>Male</term><term>Middle East</term><term>Phylogeny</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Flambées de maladies</term><term>Humains</term><term>Lutte contre l'infection</term><term>Moyen Orient</term><term>Mâle</term><term>Phylogénie</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">In 2015, the largest outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection outside the Middle East occurred in South Korea. We summarized the epidemiological, clinical, and laboratory findings of the first Korean case of MERS-CoV and analyzed whole-genome sequences of MERS-CoV derived from the patient.</p></sec><sec><title>Case presentation</title><p id="Par2">A 68-year-old man developed fever and myalgia 7 days after returning to Korea, following a 10-day trip to the Middle East. Before diagnosis, he visited 4 hospitals, potentially resulting in secondary transmission to 28 patients. On admission to the National Medical Center (day 9, post-onset of clinical illness), he presented with drowsiness, hypoxia, and multiple patchy infiltrations on the chest radiograph. He was intubated (day 12) because of progressive acute respiratory distress syndrome (ARDS) and INF-α2a and ribavirin treatment was commenced. The treatment course was prolonged by superimposed ventilator associated pneumonia. MERS-CoV PCR results converted to negative from day 47 and the patient was discharged (day 137), following rehabilitation therapy. The complete genome sequence obtained from a sputum sample (taken on day 11) showed the highest sequence similarity (99.59%) with the virus from an outbreak in Riyadh, Saudi Arabia, in February 2015.</p></sec><sec><title>Conclusions</title><p id="Par3">The first case of MERS-CoV infection had high transmissibility and was associated with a severe clinical course. The patient made a successful recovery after early treatment with antiviral agents and adequate supportive care. This first case in South Korea became a super-spreader because of improper infection control measures, rather than variations of the virus.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Park, Ys" uniqKey="Park Y">YS Park</name></author><author><name sortKey="Lee, C" uniqKey="Lee C">C Lee</name></author><author><name sortKey="Kim, Km" uniqKey="Kim K">KM Kim</name></author><author><name sortKey="Kim, Sw" uniqKey="Kim S">SW Kim</name></author><author><name sortKey="Lee, Kj" uniqKey="Lee K">KJ Lee</name></author><author><name sortKey="Ahn, J" uniqKey="Ahn J">J Ahn</name></author><author><name sortKey="Ki, M" uniqKey="Ki M">M Ki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Hy" uniqKey="Park H">HY Park</name></author><author><name sortKey="Lee, Ej" uniqKey="Lee E">EJ Lee</name></author><author><name 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Kim</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Lee, Ji Yeon" sort="Lee, Ji Yeon" uniqKey="Lee J" first="Ji Yeon" last="Lee">Ji Yeon Lee</name></noRegion><name sortKey="Chung, Eun Hee" sort="Chung, Eun Hee" uniqKey="Chung E" first="Eun Hee" last="Chung">Eun Hee Chung</name><name sortKey="Jeong, Ina" sort="Jeong, Ina" uniqKey="Jeong I" first="Ina" last="Jeong">Ina Jeong</name><name sortKey="Joh, Joon Sung" sort="Joh, Joon Sung" uniqKey="Joh J" first="Joon-Sung" last="Joh">Joon-Sung Joh</name><name sortKey="Kim, Dae Won" sort="Kim, Dae Won" uniqKey="Kim D" first="Dae-Won" last="Kim">Dae-Won Kim</name><name sortKey="Kim, Gayeon" sort="Kim, Gayeon" uniqKey="Kim G" first="Gayeon" last="Kim">Gayeon Kim</name><name sortKey="Kim, Sung Soon" sort="Kim, Sung Soon" uniqKey="Kim S" first="Sung Soon" last="Kim">Sung Soon Kim</name><name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name><name sortKey="Kim, You Jin" sort="Kim, You Jin" uniqKey="Kim Y" first="You-Jin" last="Kim">You-Jin Kim</name><name sortKey="Yun, Mi Ran" sort="Yun, Mi Ran" uniqKey="Yun M" first="Mi-Ran" last="Yun">Mi-Ran Yun</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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